Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway
Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.
Authors
- Mingzi Ouyang (ORCID: https://orcid.org/0000-0002-3418-3613)
- Yuqi Liang (ORCID: https://orcid.org/0000-0002-7481-116X)
- Dajin Pi (ORCID: https://orcid.org/0000-0002-2805-6458)
- Yingchao Wu (ORCID: https://orcid.org/0000-0002-4810-0399)
- Liushan Chen (ORCID: https://orcid.org/0000-0003-0414-4987)
- Peng Wu (ORCID: https://orcid.org/0000-0003-0447-023X)
- Qian Zuo
- Jiaqi Cui (ORCID: https://orcid.org/0000-0001-6006-4442)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fphar.2025.1532579
- Citations
- 5
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province