RGS14 binds to GNAI3 and regulates the proliferation and apoptosis of human spermatogonial stem cells by affecting PLPP2 expression and MAPK signaling
Our findings uncover a novel RGS14-GNAI3-PLPP2 regulatory axis critical for SSC homeostasis. The dysregulation of these molecules contributes to SSC dysfunction and NOA pathogenesis. These data not only elucidate RGS14's role in SSC fate determination but also identify RGS14 and its interactome as promising therapeutic targets for restoring spermatogenesis in male infertility.
Authors
- Lvjun Liu (ORCID: https://orcid.org/0009-0008-4503-6441)
- Dai Zhou (ORCID: https://orcid.org/0000-0003-4577-8898)
- Aimin Deng
- Xiangyu Chen (ORCID: https://orcid.org/0000-0002-4284-8507)
- Xiaowen Liu (ORCID: https://orcid.org/0000-0003-4139-1127)
- Lin Peng (ORCID: https://orcid.org/0009-0002-2724-8711)
- Shusheng Zhang (ORCID: https://orcid.org/0000-0003-3983-2894)
- Bang Liu (ORCID: https://orcid.org/0000-0003-3045-2019)
- Fang Zhu (ORCID: https://orcid.org/0000-0001-6234-2901)
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Reproductive & Genetic Hospital CITIC-Xiangya (CN)
- The First Hospital of Changsha (CN)
- National Engineering Research Center of Human Stem Cells (CN)
- Xiangya Hospital Central South University (CN)
- Hunan Provincial Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fcell.2025.1593595
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00