Chromene flavanones from Dalea boliviana as xanthine oxidase inhibitors: in vitro biological evaluation and molecular docking studies
Our findings lead us to propose these chromene flavanones as lead compounds for the design and development of novel XO inhibitors for treating diseases in which exacerbated activity of this enzyme is involved.
Authors
- Marı́a Gabriela Ortega (ORCID: https://orcid.org/0000-0002-2400-9099)
- Javier Echeverría (ORCID: https://orcid.org/0000-0002-1688-968X)
- Elia Pérez Aguirre
- Mariana Andrea Peralta (ORCID: https://orcid.org/0000-0001-9362-8566)
- María Daniela Santi (ORCID: https://orcid.org/0000-0002-3866-1424)
- Margot Paulino Zunini
- Melisa Fabiana Negro (ORCID: https://orcid.org/0009-0008-8145-4739)
Institutions
- Universidad de Santiago de Chile (CL)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional de Córdoba (AR)
- Universidad de la República de Uruguay (UY)
- Tissue Dynamics (Israel) (IL)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fphar.2025.1576390
- Citations
- 1
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Universidad Nacional de Córdoba
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Agencia Nacional de Promoción Científica y Tecnológica