Macrophage PKM2 depletion ameliorates hepatic inflammation and acute liver injury in mice
Our study highlights the pivotal role of macrophage PKM2 in advancing ALI, and therapeutic targeting of PKM2 may serve as a novel strategy to combat ALI.
Authors
- Jian Hong (ORCID: https://orcid.org/0000-0003-1084-3979)
- Hengdong Qu
- Weijia Ye
- Ziwei Kang (ORCID: https://orcid.org/0000-0002-1345-1252)
- Zhiwei Chen (ORCID: https://orcid.org/0000-0002-4511-2888)
- Jincheng Li (ORCID: https://orcid.org/0000-0002-0558-774X)
- Keke Zhang (ORCID: https://orcid.org/0000-0002-1381-6338)
- Jinyu Lv
- Piyu Zhao
- Ruoyan Xie
- Yiming Cui
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fphar.2025.1546045
- Citations
- 6
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province