Comprehensive biocompatibility profiling of human pancreas-derived biomaterial
Herein, we present a comprehensive <i>in vitro</i> evaluation of the cytotoxicity, hemocompatibility and immunocompatibility of dsECM to establish a concentration range where it deemed safe and biocompatible. Furthermore, dsECM-based bioinks were coaxially bioprinted and the resulting construct's biocompatibility and vascularization potential were also evaluated <i>in vivo</i>.
Authors
- Tamara Lozano‐Fernández (ORCID: https://orcid.org/0000-0002-0365-6895)
- Giuseppe Orlando (ORCID: https://orcid.org/0000-0002-6460-7974)
- Riccardo Tamburrini (ORCID: https://orcid.org/0000-0002-2916-2666)
- Lori N. Byers
- Alice A. Tomei (ORCID: https://orcid.org/0000-0002-5059-6303)
- Deborah Chaimov
- Christopher A. Fraker (ORCID: https://orcid.org/0000-0002-2010-0573)
- Amish Asthana (ORCID: https://orcid.org/0000-0002-4597-5982)
- Wonwoo Jeong (ORCID: https://orcid.org/0000-0002-9527-5976)
- Arunkumar Rengaraj (ORCID: https://orcid.org/0000-0001-8996-3265)
- Quentin Perrier
- Sang Jin Lee (ORCID: https://orcid.org/0000-0002-3899-1909)
- Amanda Gallego
- Jun Ho-Heo
Institutions
- Forest Institute (US)
- Atrium Health Wake Forest Baptist (US)
- University of Miami (US)
- Inmunotek (Spain) (ES)
- Wake Forest University (US)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fbioe.2025.1518665
- Citations
- 2
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- European Commission
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases