Chemical profile of Rhododendron luteum Sweet leaf supercritical CO2 extracts and their anti-inflammatory and antidiabetic potential
The LC-MS analyses revealed high levels of oleanolic acid, ursolic acid, and β-sitosterol, which belong to terpenes, as well as polyphenols such as syringic acid, ferulic acid, and p-coumaric acid, along with apigenin and its 7-glucoside. Among volatiles, the most prominent were limonene, eugenol, β-phenylethanol, and β-caryophyllene. <i>In vitro</i> assays showed a high hyaluronidase and moderate lipoxygenase and xanthine oxidase inhibitory activity presented by RLL supercritical extracts. Moreover, the samples were found to present α-glucosidase inhibitory activity. This may indicate the anti-inflammatory and antidiabetic potential of RLL supercritical extracts.
Authors
- Agnieszka Krajewska (ORCID: https://orcid.org/0000-0002-0010-6089)
- Andriy Prokopiv (ORCID: https://orcid.org/0000-0003-1690-4090)
- Lena Łyko (ORCID: https://orcid.org/0000-0003-3731-7936)
- Marta Olech (ORCID: https://orcid.org/0000-0002-2838-550X)
- Danuta Kalemba (ORCID: https://orcid.org/0000-0002-4018-5260)
- Urszula Gawlik‐Dziki (ORCID: https://orcid.org/0000-0002-7308-4335)
- Renata Nowak (ORCID: https://orcid.org/0000-0003-4952-3147)
Institutions
- Medical University of Lublin (PL)
- University of Life Sciences in Lublin (PL)
- Lodz University of Technology (PL)
- Lviv University (UA)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fchem.2025.1576852
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00