Suicidal thoughts and behaviors associated with fluoroquinolone antibiotics: a real-world pharmacovigilance analysis
The analysis of reported cases of suicidal thoughts and behaviors in the FAERS database does not indicate an overall safety signal associated with fluoroquinolones (FQs) at present. Subgroup analysis revealed a slight increase in the RORs for suicidal thoughts and behaviors in the <18 years and the 18-24 years age group; however, no significant safety signal was detected based on the EBGM05s in these populations. Further comprehensive and prospective studies are necessary to confirm and validate these findings.
Authors
- Tingting Lu (ORCID: https://orcid.org/0000-0002-9332-2679)
- Congqin Chen (ORCID: https://orcid.org/0000-0003-1768-1298)
- Lingqing Ding
- Lijuan Yang (ORCID: https://orcid.org/0000-0002-6000-6530)
- Jie Xiao (ORCID: https://orcid.org/0000-0002-2871-4086)
- Xiwen Li (ORCID: https://orcid.org/0000-0002-5092-854X)
Institutions
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fphar.2025.1556159
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00