A computational account of joint SSRI and anti-inflammatory treatment
This study is a first step to mechanistically understand the intricate link between the immune system and depression, the role of inflammation and potential treatments. It explores the impact of anti-depressant and anti-inflammatory drug treatments and assesses their relevance with regard to depression severity.
Authors
- Dimitris A. Pinotsis (ORCID: https://orcid.org/0000-0002-6865-8103)
- Helen S. Mayberg (ORCID: https://orcid.org/0000-0002-1672-2716)
- Melissa Reneaux (ORCID: https://orcid.org/0000-0002-9850-8464)
- Karl Friston (ORCID: https://orcid.org/0000-0001-7984-8909)
Institutions
- McGovern Institute for Brain Research (US)
- Wellcome Centre for Human Neuroimaging (GB)
- Institute of Cognitive and Brain Sciences (US)
- University College London (GB)
- University of Petroleum and Energy Studies (IN)
- Massachusetts Institute of Technology (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1472732
- Citations
- 3
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Medical Research Council
- Economic and Social Research Council