Combinations of posaconazole and tacrolimus are effective against infections with azole-resistant Aspergillus fumigatus
<i>In vitro</i> and <i>in vivo</i> findings confirm that posaconazole may offer therapeutic benefits for treating <i>A. fumigatus</i> infections in patients receiving tacrolimus. These results warrant further confirmation in mice and exploration of their clinical implications.
Authors
- Karin Thevissen (ORCID: https://orcid.org/0000-0003-0275-9072)
- Eliane Vanhoffelen (ORCID: https://orcid.org/0000-0003-1938-254X)
- Agustin Reséndiz-Sharpe (ORCID: https://orcid.org/0000-0002-2000-1030)
- Bruno P.A. Cammue (ORCID: https://orcid.org/0000-0001-8087-4768)
- Greetje Vande Velde (ORCID: https://orcid.org/0000-0002-5633-3993)
- Katrien Lagrou (ORCID: https://orcid.org/0000-0001-8668-1350)
- Eva Van Braeckel (ORCID: https://orcid.org/0000-0002-7242-0747)
- Tine Van Win (ORCID: https://orcid.org/0009-0001-0657-1328)
Institutions
- Ghent University Hospital (BE)
- Ghent University (BE)
- Ecologie microbienne (FR)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fcimb.2025.1550457
- Citations
- 4
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Fonds Wetenschappelijk Onderzoek
- Universitair Ziekenhuis Gent
- KU Leuven
- Universiteit Gent