A Case of Guillain-Barré Syndrome Possibly Associated With COVID-19 Infection

Guillain-Barré syndrome (GBS) is a neurological disorder characterized by progressive and symmetric muscle weakness accompanied by the absence or depression of deep tendon reflexes. It is typically associated with a preceding viral infection, such as the Epstein-Barr virus, cytomegalovirus, hepatitis E virus, and Zika virus, or bacterial pathogens like <i>Campylobacter jejuni</i> and <i>Mycoplasma pneumoniae.</i> Recently, rare cases of GBS have been reported following infection with COVID-19, suggesting a potential association between SARS-CoV-2 and GBS. In this report, we present a clinically and diagnostically confirmed case of GBS following COVID-19 reinfection, which supports emerging data on the neurological complications associated with subsequent episodes of infection by the novel coronavirus.

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Publication Details

Journal
Cureus
Published
2025-04-24
DOI
https://doi.org/10.7759/cureus.82954
Primary Topic
Peripheral Neuropathies and Disorders
Type
article
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0.00
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article

A Case of Guillain-Barré Syndrome Possibly Associated With COVID-19 Infection

Rafail Giannas, Evgenia Skafida, Louiza Klironomou
Cureus
Peripheral Neuropathies and Disorders
article

A Case of Guillain-Barré Syndrome Possibly Associated With COVID-19 Infection

Rafail Giannas, Evgenia Skafida, Louiza Klironomou
article en

Abstract

Guillain-Barré syndrome (GBS) is a neurological disorder characterized by progressive and symmetric muscle weakness accompanied by the absence or depression of deep tendon reflexes. It is typically associated with a preceding viral infection, such as the Epstein-Barr virus, cytomegalovirus, hepatitis E virus, and Zika virus, or bacterial pathogens like <i>Campylobacter jejuni</i> and <i>Mycoplasma pneumoniae.</i> Recently, rare cases of GBS have been reported following infection with COVID-19, suggesting a potential association between SARS-CoV-2 and GBS. In this report, we present a clinically and diagnostically confirmed case of GBS following COVID-19 reinfection, which supports emerging data on the neurological complications associated with subsequent episodes of infection by the novel coronavirus.

CureusVol. 17(4)
National and Kapodistrian University of Athens (GR), York General Hospital (US), General Hospital Asklepieio Voulas (GR)
Openalex Percentile: Top 85%
Peripheral Neuropathies and Disorders
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