Abstract SY41-01: Do individual cancer cells learn to become therapy resistant

Abstract Do individual cancer cells learn to become therapy resistant? Do cells remember their past experiences? DNA is one way to encode these past experiences, but cannot generally be altered within a lifetime. How, then, can cells learn? We present data showing that cancer cells, in the context of therapy resistance, remember their past, and this past can influence their future. We find the molecular mechanism by which such regulatory flexibility is achieved. We think this mechanism may open new avenues for treating therapy-resistant tumors. Citation Format: Arjun Raj. Do individual cancer cells learn to become therapy resistant [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_2):Abstract nr SY41-01.