Abstract LB341: A meta-analysis of cancer neoantigens curated from the literature

Abstract The Cancer Epitope Database and Analysis Resource (CEDAR) aggregates cancer epitope data from peer-reviewed studies, providing a structured repository of epitope-specific T cell, antibody, and MHC ligand assays. Neoantigens, arising from somatic mutations in cancer cells, represent a class of tumor-specific epitopes with potential for precision immunotherapy and as biomarkers for patient prognosis and therapeutic response. The curated neoantigen dataset in CEDAR includes data on over 23,000 neopeptides that were experimentally tested for T cell recognition. Around 4,000 neoepitopes had at least one reported positive T cell assay outcome. Our study harnesses CEDAR’s curated dataset to conduct a meta-analysis on neoantigens across various cancers, identifying factors contributing to neoantigen immunogenicity and their prevalence among patient populations. Citation Format: Zeynep Kosaloglu-Yalcin, Nina Blazeska, Hannah Carter, Morten Nielsen, Stephen Schoenberger, Alessandro Sette, Bjoern Peters. A meta-analysis of cancer neoantigens curated from the literature [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_2):Abstract nr LB341.