Terpenoids from <i>Chloranthus holostegius</i> with Anti‐inflammatory Activities
Five new terpenoids, including one isocamphane-type monoterpenoid (1), one labdane-type diterpenoid (2), and three cadinane-type sesquiterpenoids (3‒5), were isolated from the whole plant of Chloranthus holostegius. A combination of spectral analysis (HR-ESI-MS, UV, IR, and 1D/2D NMR), quantum chemical calculations (NMR/ECD), and X-ray crystallography were employed in the structural characterization. In anti-inflammatory assays, all isolates were evaluated by examination of their inhibitory effects on nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells, and compounds 1 and 5 exhibited moderate inhibitory activity against NO release, with IC<sub>50</sub> values of 21.16 ± 1.37 and 18.03 ± 1.24 µM, respectively.
Authors
- Ting Lu (ORCID: https://orcid.org/0000-0003-1944-8625)
- Wen Li (ORCID: https://orcid.org/0000-0002-3975-3312)
- Wei Wu (ORCID: https://orcid.org/0000-0003-3666-1217)
- Miao Wang (ORCID: https://orcid.org/0000-0003-0802-996X)
Institutions
- Jinan University (CN)
- The First People's Hospital of Shunde (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1002/cbdv.202501008
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Jinan University
- Fundamental Research Funds for the Central Universities