Abstract SY47-02: Metabolic interactions driving metastasis growth

Abstract Metastasis formation is the leading cause of death in cancer patients. We find that metabolic rewiring is a liability of metastasizing cancer cells. For example, we discovered that extracellular remodeling of the metastatic niche, a process essential to metastasis formation, requires a transcriptional-independent regulation via the metabolites. Moreover, we provide knowledge on intratumor heterogeneity of metabolism and its role in pre-metastatic niche and metastasis formation. Thus, we study the metabolism of metastasizing cancer cells with the goal to define novel therapeutic strategies. Citation Format: Sarah-Maria Fendt. Metabolic interactions driving metastasis growth [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_2):Abstract nr SY47-02.