Abstract LB271: Faith in Cancer Equity: A community-centered approach to eliminating enrollment barriers to early phase trials in Black communities in Los Angeles County

Abstract Introduction: Los Angeles County has a population where more than 58% identify as Black or Hispanic/Latinx, nearly double the national Census average of 33%. However, according to the FDA, these groups are significantly underrepresented in clinical trial data, comprising only 19% of participants. Our project seeks to increase education on clinical trials in Black communities, develop culturally relevant materials, and address cancer prevention, screenings, and treatment barriers. Materials and Methods: A key element of our approach was the Faith in Cancer Equity Concert Tour, a partnership with churches across Los Angeles. By leveraging the trusted influence of faith leaders, we shared critical information about Black cancer health equity and research at the USC Norris Comprehensive Cancer Center. The tour included an educational presentation, Open Q&A sessions, and videos featuring cancer patients and survivors. These events emphasized the importance of clinical trials, addressed concerns, and used faith, equity, and hope to overcome historical reluctance toward participation. Discussion/Results: Registration Survey data from 180 participants provided key insights into health histories and attitudes toward clinical trials. Of those surveyed, 123 reported a family history of cancer, most commonly breast, prostate, and colon cancers. 13 participants were cancer patients or survivors, but only one had been offered a clinical trial. 116 respondents expressed uncertainty or reluctance about participating in trials, and cancer screening rates were low—only 26% of men had prostate screenings, and 37% of all participants had colon screenings. These findings highlight significant gaps in cancer screening and clinical trial engagement, emphasizing the need for further education and guiding future efforts, influenced by strong community interest and detailed questions that will shape ongoing outreach. Summary/Conclusion: The Faith in Cancer Equity Tour successfully addressed barriers to cancer care and clinical trial participation in the Black community, promoting early detection screenings and shifting perceptions of clinical trials. The data revealed reluctance toward trials and low screening rates for prostate and colon cancers, highlighting areas for intervention. Strong community engagement showed that culturally relevant education can increase participation. Attendees’ questions emphasized the need for tailored resources. Moving forward, we will use this feedback and data to guide our efforts to promote cancer health equity, raise awareness, encourage early detection, and empower informed decisions to advance cancer treatment and equity for all. Citation Format: Essence Wynter, Anthony El-Khoueiry, Chanita Hughes-Halbert, Lourdes Baezconde-Garbanati. Faith in Cancer Equity: A community-centered approach to eliminating enrollment barriers to early phase trials in Black communities in Los Angeles County [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_2):Abstract nr LB271.