Synthesis of <i>trans</i>‐2‐(Disubstituted‐amino)alkenyl Polyoxyperfluoroalkyl Ketones from Tertiary Amines and Perfluoroalkyl Ether Carboxylates Featuring “–<scp>CF<sub>2</sub>O</scp>–” Units<sup>†</sup>
Comprehensive Summary A one‐pot transformation of aliphatic and aromatic tertiary amines to novel fluorinated enaminones has been developed, utilizing perfluoroalkyl ether carboxylates (PFECA salts) featuring “–CF 2 O–” units as the fluorine‐containing reagents. Carbonyl fluoride, acyl fluorides and anhydrides by thermal decomposition of these PFECA salts were proposed to act as key active species that trigger the tandem oxidation–acylation process of tertiary amines, through enamine intermediates.
Authors
- Qijian Ni (ORCID: https://orcid.org/0000-0002-3135-1271)
- Cheng‐Ying Wu (ORCID: https://orcid.org/0000-0001-5999-0780)
- Yong Guo (ORCID: https://orcid.org/0000-0002-9703-0649)
- Shiyu Zhao (ORCID: https://orcid.org/0000-0002-4946-6034)
- Ji‐Chang Xiao (ORCID: https://orcid.org/0000-0001-9679-3292)
Institutions
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Chinese Journal of Chemistry
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1002/cjoc.70055
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China