Etomidate-Induced myoclonus in Sprague‒Dawley rats involves the activation of neocortical Calpain-2 and its decrement on KCC2 protein
Calpain-2 was involved in the process of etomidate-induced myoclonus and NMDAR activity by promoting the decrement of KCC2 protein and exerting the excitability. Vitamin E, as a natural antioxidant, can effectively prevent etomidate-induced myoclonus and does not affect recovery after etomidate anesthesia in rats.
Authors
- Xinghao Wang (ORCID: https://orcid.org/0000-0001-5751-7383)
- Yan Feng (ORCID: https://orcid.org/0000-0002-6790-6099)
- Yan‐Qiong Cheng
Institutions
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12871-025-03065-3
- Citations
- 4
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 3.64