Anlotinib inhibits c-MET and ITGA2 in the treatment of anaplastic thyroid carcinoma
This study confirmed the therapeutic effect of anlotinib on ATC via in vivo and in vitro experiments. In addition, preliminary studies suggest that the mechanism of anlotinib in treating ATC may be to alter the high invasiveness of ATC cells by inhibiting c-MET signaling pathway.
Authors
- Haohan Huang
- Shunshun Zhao
- Qiuyu Meng (ORCID: https://orcid.org/0000-0002-0621-6414)
- Ruochuan Cheng (ORCID: https://orcid.org/0000-0003-1292-4780)
- Tingting Yang (ORCID: https://orcid.org/0000-0002-8585-0922)
- Min Zhang (ORCID: https://orcid.org/0000-0001-5812-9518)
- Chuanyuan Liu
- Mingyao Meng (ORCID: https://orcid.org/0000-0002-9766-414X)
- Xiaodan Wang (ORCID: https://orcid.org/0000-0002-5632-9177)
- Bin Liu (ORCID: https://orcid.org/0000-0003-2189-9476)
- Yanjun Su (ORCID: https://orcid.org/0009-0002-0725-1243)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Yunnan Center for Disease Control And Prevention (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12957-025-03810-5
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kunming Medical University
- Yunnan Provincial Science and Technology Department