Germline DNA Repair Gene Mutations and Clonal Hematopoiesis (CH) in 24,849 Patients with BRCA-Associated Cancers
When accounting for age at time of testing, pathogenic germline alterations in DNA repair genes were associated with an increased risk of CH only among patients with breast cancer, but not in those with ovarian, pancreatic, or prostate cancers.
Authors
- Stamatina Fragkogianni (ORCID: https://orcid.org/0000-0002-5960-8921)
- Emmanuel S. Antonarakis (ORCID: https://orcid.org/0000-0003-0031-9655)
- Anne Sonnenschein
- Calvin Chao (ORCID: https://orcid.org/0000-0002-9704-9227)
- Ali T. Arafa
- Catherine Handy Marshall (ORCID: https://orcid.org/0000-0002-2653-4110)
- Ellen Jaeger (ORCID: https://orcid.org/0009-0005-1386-614X)
- Lukasz P. Gondek (ORCID: https://orcid.org/0000-0002-1551-3496)
- Jun Luo (ORCID: https://orcid.org/0000-0002-1414-473X)
- Elizabeth Mauer (ORCID: https://orcid.org/0009-0001-8033-0696)
Institutions
- University of Minnesota (US)
- Johns Hopkins University (US)
- Tempus Labs (United States) (US)
- University of Minnesota Medical Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3390/cancers17091432
- Citations
- 3
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- U.S. Department of Defense
- Commonwealth Fund
- National Cancer Institute