Molecular subtyping of endometrial cancer via a simplified one-step NGS classifier, ARID1A and ZFHX4 mutations help further subclassify CNL/MSI-H patients
This simplified one-step NGS panel can effectively subgroup EC patients into four prognostically different subtypes. New biomarkers are able to potentially refine the classification of patients with CNL/MSI-H subtypes into groups with distinct clinical outcomes.
Authors
- Yulong Mu
- Shuaixin Wang (ORCID: https://orcid.org/0000-0003-1781-3959)
- Linhan Chin (ORCID: https://orcid.org/0000-0001-5034-5670)
- Changbin Zhu
- Aijun Yin (ORCID: https://orcid.org/0000-0003-4159-5146)
- Zhan Huang (ORCID: https://orcid.org/0000-0002-4024-1592)
- Xinyue Ma (ORCID: https://orcid.org/0000-0003-3463-9809)
- Chenggong Sun
- Ruifen Dong (ORCID: https://orcid.org/0009-0001-5829-8327)
- Zeng Yuan (ORCID: https://orcid.org/0000-0002-6550-5179)
- Qiuli Teng
Institutions
- Shandong University (CN)
- Dian Diagnostics (China) (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s13000-025-01652-z
- Citations
- 2
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Key Technologies Research and Development Program