Development and study of a herbal composition that is promising in the complex therapy of tuberculosis

Introduction. Tuberculosis is a socially significant disease both in the territory of the Russian Federation and worldwide. The high resistance of Mycobacterium tuberculosis and the high toxicity of existing chemotherapeutic drugs necessitate the development of new medications. Plant-based medicinal agents are promising for complex tuberculosis therapy, as they can support the patient’s weakened body, reduce the side effects of chemotherapeutic drugs, and strengthen lung tissue. Aim. To develop the plant-based medicinal composition for the complex therapy of tuberculosis. Materials and methods. Fourteen pharmacopoeial types of medicinal plant raw materials and three plant-based compositions derived from them were analyzed. The studies were conducted according to the methodologies outlined in the State Pharmacopoeia of the Russian Federation (15th edition). Results and discussion. Based on scientific data, three compositions of plant-based formulations for the complex therapy of pulmonary tuberculosis were proposed. The quantitative content of the main groups of biologically active substances (BAS) – polysaccharides, tannins, flavonoids, and ascorbic acid – was studied in 14 types of medicinal plant raw materials and three plant-based compositions. A plant-based composition variant with the maximum BAS content was identified. The mutual influence of components on the extraction efficiency of BAS from the raw materials was established. Conclusion. The plant-based medicinal composition for the complex therapy of tuberculosis was developed, and the main groups of BAS in its hydrophilic fraction were quantitatively determined.