White Matter Hyperintensity Load Independent From the Stroke Lesion Is Associated With Chronic Aphasia Severity and Treatment Outcome
Given the regional effect of the stroke lesion, whole-brain ratings can overestimate the WMH burden and thus reduce the accuracy in evaluating small vessel disease effects on stroke recovery and aphasia severity, particularly therapy-related neuroplasticity. This is an important detail that should be considered in mechanistic studies of small vessel disease, brain health, and stroke recovery.
Authors
- Julius Fridriksson (ORCID: https://orcid.org/0000-0001-9255-2045)
- Argye E. Hillis (ORCID: https://orcid.org/0000-0002-5192-1171)
- Natalie Busby (ORCID: https://orcid.org/0000-0001-7117-7899)
- Roger Newman‐Norlund (ORCID: https://orcid.org/0000-0002-0966-1070)
- Leonardo Bonilha (ORCID: https://orcid.org/0000-0002-6153-8942)
- Lisa Johnson (ORCID: https://orcid.org/0000-0002-8727-7269)
- Sigfus Kristinsson (ORCID: https://orcid.org/0000-0002-0459-5369)
- Chris Rorden (ORCID: https://orcid.org/0000-0002-7554-6142)
- Rebecca Roth (ORCID: https://orcid.org/0000-0002-8620-3946)
Institutions
- Emory Healthcare (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of South Carolina (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Stroke
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1161/strokeaha.124.046710
- Citations
- 1
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 1.43