An observational study of the lung microbiome and lung function in young children with cystic fibrosis across two countries with differing antibiotic practices
Lung microbial diversity in infants with CF varied between the two countries, particularly during early infancy. A shift in the lung microbiome toward a higher relative abundance of Streptococcus was associated with reduced pulmonary function.
Authors
- Don B. Sanders (ORCID: https://orcid.org/0000-0001-6265-6249)
- Wangfei Wang (ORCID: https://orcid.org/0000-0002-7401-2421)
- Christian Ascoli (ORCID: https://orcid.org/0000-0002-7424-2710)
- Nicole K. Nemsick
- Mladen Rasic (ORCID: https://orcid.org/0000-0002-7377-8193)
- Stephen M. Stick (ORCID: https://orcid.org/0000-0002-5386-8482)
- David L. Perkins (ORCID: https://orcid.org/0000-0002-0164-6036)
- Joseph Hatch (ORCID: https://orcid.org/0000-0003-4703-6177)
- Y.S Chen (ORCID: https://orcid.org/0009-0005-0903-9918)
- Stephanie D. Davis (ORCID: https://orcid.org/0000-0002-9390-0651)
- Sarath Ranganathan (ORCID: https://orcid.org/0000-0002-6975-0307)
- Patricia W. Finn (ORCID: https://orcid.org/0000-0001-6936-103X)
- Ashley R. Deschamp
- Thomas Ferkol
Institutions
- University of North Carolina at Chapel Hill (US)
- University of North Carolina Health Care (US)
- University of New Mexico (US)
- The University of Western Australia (AU)
- Government of Western Australia Department of Health (AU)
- University of Illinois Chicago (US)
- Children's Hospital & Medical Center (US)
- Murdoch Children's Research Institute (AU)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Microbial Pathogenesis
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.micpath.2025.107628
- Citations
- 2
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 3.04