Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury
The results of this study confirm that Eda-Dex exerts neuroprotective effects by synergistically inhibiting oxidative stress and inflammation via the NRF2/ARE and NF-κB/AIM2 pathways in CIRI rats.
Authors
- Can Zhu (ORCID: https://orcid.org/0000-0001-6604-6173)
- Binsheng He (ORCID: https://orcid.org/0000-0002-2232-4634)
- Jianming Li (ORCID: https://orcid.org/0000-0002-5012-0989)
- Hui Zhang (ORCID: https://orcid.org/0000-0003-4513-5606)
- Ling Deng (ORCID: https://orcid.org/0009-0007-2220-8370)
- Xingyu Zhou (ORCID: https://orcid.org/0000-0002-5880-105X)
- Laifa Wang
Institutions
- Changsha Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fphar.2025.1581320
- Citations
- 14
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 11.79
Funders
- Education Department of Hunan Province
- Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province