Impact of different chemical debridement agents on early cellular responses to titanium dental implants: A transcriptome-based in vitro study on peri-implant tissue regeneration
Commercial agents like Perisolv and Paroex impair hBMSC function, with Paroex demonstrating significant cytotoxicity. H2O2 exhibits toxicity, particularly to hBMSCs. Poloxamer improves cell attachment and growth. Given these findings, careful selection of debridement agents is critical to balance cleaning efficacy and cytocompatibility. The adverse effects on hBMSCs necessitate prompt removal postapplication. Further research on biomaterials supporting tissue regeneration postdebridement is needed to restore peri-implant health.
Authors
- Håvard Jostein Haugen (ORCID: https://orcid.org/0000-0002-6690-7233)
- Ståle Petter Lyngstadaas (ORCID: https://orcid.org/0000-0002-6361-7644)
- Ólafur E. Sigurjónsson (ORCID: https://orcid.org/0000-0002-4968-842X)
- Dirk Linke (ORCID: https://orcid.org/0000-0003-3150-6752)
- Qianli Ma (ORCID: https://orcid.org/0009-0006-9371-955X)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-1715-8758)
Institutions
- University of Oslo (NO)
- National University Hospital of Iceland (IS)
Publication Details
- Journal
- Colloids and Surfaces B Biointerfaces
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.colsurfb.2025.114727
- Citations
- 3
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- China Scholarship Council
- Norges Forskningsråd