The therapeutic potential of a polyunsaturated fatty acid-enriched high-fat diet in Leigh syndrome: Insights from a preclinical model
Dietary interventions, such as a PUFA-enriched HFD, may alleviate systemic inflammation, partially correct metabolic imbalances, and mitigate specific disease phenotypes in Leigh syndrome, warranting further investigation into the underlying mechanisms and broader therapeutic applications.
Authors
- Karin Terburgh (ORCID: https://orcid.org/0000-0001-5700-6890)
- Roan Louw (ORCID: https://orcid.org/0000-0002-6542-8644)
- Luciano Willemse
Institutions
- North-West University (ZA)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.bbadis.2025.167873
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- North-West University