Ginsenoside Rg1 Attenuates Muscle Atrophy in Hyperglycemic Conditions, Inactivity and Protein Deprivation Models via AKT/mTOR Pathway Activation
Ginsenoside Rg1 exhibits significant protective properties against muscle atrophy under hyperglycemic conditions and in experimental models of immobilization and protein restriction, primarily mediated through activation of the AKT/mTOR signaling pathway. These findings establish Rg1 as a promising therapeutic candidate for the treatment of muscle atrophy.
Authors
- Yan Huang (ORCID: https://orcid.org/0009-0003-8991-7690)
- Jing Li (ORCID: https://orcid.org/0000-0002-8030-7146)
- Li Zhang (ORCID: https://orcid.org/0000-0003-0595-0761)
- Xu He (ORCID: https://orcid.org/0000-0002-2593-9861)
- Ying Zhou (ORCID: https://orcid.org/0009-0007-8679-6124)
- Jun Chen (ORCID: https://orcid.org/0000-0002-6513-9084)
- Yan Li (ORCID: https://orcid.org/0000-0002-5814-0781)
Institutions
- Kunming University of Science and Technology (CN)
- First People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- Current Molecular Medicine
- Published
- 2025-04-23
- DOI
- https://doi.org/10.2174/0115665240355315250414051525
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81