SARS-CoV-2 lineage-dependent temporal phylogenetic distribution and viral load in immunocompromised and immunocompetent individuals
Immunocompromised patients have lower viral loads, probably due to their later diagnosis compared to NICs and oncology patients, who have better access to on-site SARS-CoV-2 testing and follow-up. In addition, mutational profiles differ between the two groups, with immunocompromised hosts accumulating more mutations compared to NICs.
Authors
- Sébastien Ottaviani (ORCID: https://orcid.org/0000-0003-2250-1503)
- Sylvain Choquet (ORCID: https://orcid.org/0000-0002-7791-0470)
- Romane Guilbaud
- Jean‐Philippe Spano (ORCID: https://orcid.org/0000-0002-3921-2479)
- Vincent Cálvez (ORCID: https://orcid.org/0009-0002-6855-3472)
- Valentine Marie Ferré (ORCID: https://orcid.org/0000-0002-2196-6141)
- Jade Ghosn (ORCID: https://orcid.org/0000-0003-2914-959X)
- Quentin Le Hingrat (ORCID: https://orcid.org/0000-0001-9017-4941)
- Zahir Amoura (ORCID: https://orcid.org/0000-0003-0292-9043)
- Stéphane Marot (ORCID: https://orcid.org/0000-0003-4438-5793)
- P. Cacoub (ORCID: https://orcid.org/0000-0002-6727-4992)
- Romain Coppée (ORCID: https://orcid.org/0000-0002-3024-5928)
- Benoı̂t Barrou (ORCID: https://orcid.org/0000-0001-7128-1565)
- Anne‐Geneviève Marcelin (ORCID: https://orcid.org/0000-0003-4808-8999)
- Éric Daugas (ORCID: https://orcid.org/0000-0001-7256-7979)
- Laura D. Kramer (ORCID: https://orcid.org/0000-0002-8707-0778)
- Antoine Bridier‐Nahmias (ORCID: https://orcid.org/0000-0002-0376-6840)
- Diane Descamps (ORCID: https://orcid.org/0000-0002-6556-1525)
- Ève Todesco (ORCID: https://orcid.org/0000-0002-9260-8616)
- Charlotte Charpentier (ORCID: https://orcid.org/0000-0002-6441-7054)
- Gérard Zalcman
- Karen Zafilaza (ORCID: https://orcid.org/0009-0000-2071-9395)
- Mathilde Salpin (ORCID: https://orcid.org/0000-0002-0110-1589)
- Richard Dorent (ORCID: https://orcid.org/0000-0002-6159-1372)
- Martine Louet
- Tiphaine Goulenok (ORCID: https://orcid.org/0000-0003-3680-6682)
- Valentin Leducq (ORCID: https://orcid.org/0000-0002-6817-6227)
- Antoine Fauchois
- Anna-Maria Franco Yusti
- Valérie Pourcher (ORCID: https://orcid.org/0000-0002-3879-1480)
- Cathia Soulié (ORCID: https://orcid.org/0009-0008-2032-4148)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpitaux Universitaires Paris-Ouest (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12985-025-02711-z
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Styrelsen för Internationellt Utvecklingssamarbete
- Agence Nationale de la Recherche