Curcumin-Based Virtual Screening Identifies Inhibitors of SARS-CoV-2 Spike Protein and ACE2 Receptor Binding
Curcumin provides a scaffold for identifying novel compounds with potential antiviral activity. Further studies on compound Cu-1 could yield on optimizing its structure to increase activity targeting the RBD of the S glycoprotein.
Authors
- Alma D. Paz-González (ORCID: https://orcid.org/0000-0002-0938-6304)
- Gildardo Rivera (ORCID: https://orcid.org/0000-0001-9842-4167)
- Timoteo Delgado‐Maldonado (ORCID: https://orcid.org/0000-0001-8915-7351)
- Guadalupe Rojas‐Verde (ORCID: https://orcid.org/0000-0001-8350-4180)
- Eyra Ortíz-Pérez (ORCID: https://orcid.org/0000-0003-3800-0228)
- Luis D. González-Morales (ORCID: https://orcid.org/0000-0001-5799-864X)
Institutions
- Universidad Autónoma de Nuevo León (MX)
- Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-04-25
- DOI
- https://doi.org/10.2174/0115734064371154250414064157
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50