The active metabolite of Epimedii Folium promotes hippocampal neurogenesis in APP/PS1 mice by alleviating mitochondrial dysfunction

The results demonstrated that ICS II exhibited the strongest capacity to promote APP-NSC proliferation (P < 0.01, η<sup>2</sup> = 0.845), followed by Icariin and Icaritin. ICS II treatment significantly ameliorated cognitive deficits (<i>P</i> < 0.01, η<sup>2</sup> = 0.883), neuronal damage, and impairments in neurogenesis in adult APP/PS1 mice. Moreover, ICS II rescued mitochondrial damage by upregulating fusion proteins (Mfn1 and Mfn2) and downregulating fission proteins (p-Drp1/Drp1 and Mff); however, these protective effects were negated by Rot administration. In conclusion, this study identifies ICS II as one of the most effective metabolites of EF, promoting hippocampal neurogenesis and alleviating mitochondrial dysfunction in APP/PS1 mice, thereby offering promising therapeutic potential for AD.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-04-25
DOI
https://doi.org/10.3389/fphar.2025.1546256
Citations
3
Primary Topic
Medicinal Plant Pharmacodynamics Research
Type
article
Field-Weighted Citation Impact
4.67

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article

The active metabolite of Epimedii Folium promotes hippocampal neurogenesis in APP/PS1 mice by alleviating mitochondrial dysfunction

Ye-Xin Zhang, Zhuang Cui, Dongyu Min, Yufeng Shen et al.
3 citations
Frontiers in Pharmacology
Medicinal Plant Pharmacodynamics Research
4.67
article

The active metabolite of Epimedii Folium promotes hippocampal neurogenesis in APP/PS1 mice by alleviating mitochondrial dysfunction

Ye-Xin Zhang, Zhuang Cui, Dongyu Min, Yufeng Shen, Shengzhou Shan, Honghe Xiao, Jingxian Yang, Tong Li, Zhili Xu, Di Xue, Yi-Jun Shi, Jia-Ming Bai, Deqiang Dou
article en
3 citations

Abstract

The results demonstrated that ICS II exhibited the strongest capacity to promote APP-NSC proliferation (P < 0.01, η<sup>2</sup> = 0.845), followed by Icariin and Icaritin. ICS II treatment significantly ameliorated cognitive deficits (<i>P</i> < 0.01, η<sup>2</sup> = 0.883), neuronal damage, and impairments in neurogenesis in adult APP/PS1 mice. Moreover, ICS II rescued mitochondrial damage by upregulating fusion proteins (Mfn1 and Mfn2) and downregulating fission proteins (p-Drp1/Drp1 and Mff); however, these protective effects were negated by Rot administration. In conclusion, this study identifies ICS II as one of the most effective metabolites of EF, promoting hippocampal neurogenesis and alleviating mitochondrial dysfunction in APP/PS1 mice, thereby offering promising therapeutic potential for AD.

Frontiers in PharmacologyVol. 16
Liaoning University of Traditional Chinese Medicine (CN), Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Liaoning Province, Liaoning University, Liaoning University of Traditional Chinese Medicine
Openalex Percentile: Top 6%
Medicinal Plant Pharmacodynamics Research
4.67
DOIOpen Access PDFOpenAlex
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