Influence of griseofulvin on intestinal microbiota in the treatment of microsporia in rural children

Objective. To evaluate the influence of duration of griseofulvin application on intestinal microbiota in children, namely rural inhabitants, with microsporia of the scalp. Material and methods. Colonic microbiota was studied by bacteriological analysis before treatment, on the 10th and 20th days of treatment with griseofulvin administered orally at a daily dose of 21—22 mg/kg in 46 patients aged from 3 to 12 years with microsporia of the scalp. Results. The therapy’s full clinical effect, including the absence of fluorescence and elimination of the causative agent in the foci, has been noted on the 31.01±2.85th day of the treatment. Bifido-dominant content of the intestinal microflora predominated before the treatment in the children’s microbiota. There has been a decrease in mean concentrations of bifidobacteria up to 106 CFU/g (40.0% reduction) and lactobacteria up to 105 CFU/g (28.6% reduction) (p<0.05) compared to the baseline with a preservation of the total number of escherichia and enterobacteria concentration of 1.0∙106 CFU/g on the therapy by the 20th day. Conclusion. A personalized approach to combined therapy with griseofulvin in microsporia, with prescription of drugs that positively affect the species composition of the intestinal microflora, is needed.