The Prognostic Impact of the Tumor Immune Microenvironment in Synovial Sarcoma: An Immunohistochemical Analysis Using Digital Pathology and Conventional Interpretation
The tumor immune microenvironment in sarcomas is a complex system that requires further investigation to fully understand its impact on tumorigenesis and patient clinical outcomes. Our results demonstrate that a higher amount of intratumoral CD163-positive macrophage infiltrate is associated with an increased OS and DSS. Our findings show that digital pathology is more precise than subjective quantitative analysis.
Authors
- Francisco Giner (ORCID: https://orcid.org/0000-0003-0765-7120)
- Mónica Espino
- Emilio Medina-Ceballos (ORCID: https://orcid.org/0009-0003-6022-0910)
- Antonio Llombart-Bosch (ORCID: https://orcid.org/0000-0001-9205-103X)
- Begoña Heras-Morán
- Samuel Navarro (ORCID: https://orcid.org/0000-0001-5016-5653)
- Isidro Machado (ORCID: https://orcid.org/0000-0001-7318-1330)
Institutions
- Universitat de València (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Fundación Instituto Valenciano de Oncología (ES)
- Hospital Quirónsalud Barcelona (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Journal of Personalized Medicine
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3390/jpm15050169
- Citations
- 4
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.07