SAMHD1 deficiency enhances macrophage-mediated clearance of Salmonella Typhimurium via NF-κB activation in zebrafish
These findings highlight the evolutionary conserved functions of SAMHD1 in the negative regulation of the inflammatory response of vertebrates and reveal, for the first time, a critical role for SAMHD1 in the regulation of NF-κB in macrophages to clear intracellular bacterial infection.
Authors
- Juan M. Lozano‐Gil (ORCID: https://orcid.org/0000-0002-0422-9887)
- Sergio Candel (ORCID: https://orcid.org/0000-0001-7919-6584)
- Víctoriano Mulero (ORCID: https://orcid.org/0000-0001-9527-0211)
- Francisco J. Martínez-Morcillo (ORCID: https://orcid.org/0000-0002-9025-5191)
- Diana García‐Moreno (ORCID: https://orcid.org/0000-0002-1521-2327)
- Alicia Martínez-López
- Sylwia D. Tyrkalska (ORCID: https://orcid.org/0000-0001-6654-0163)
- Constantino Abenza-Olmos
Institutions
- Instituto de Salud Carlos III (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1509725
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Instituto de Salud Carlos III