Celastrol modulates damage of renal tissues in Immunoglobulin A nephropathy via targeting TGase-2/HMGB1 signaling pathway
Our study findings provide evidence supporting the efficacy of celastrol in treating IgAN. The potential underlying mechanisms involve the reduction of cell proliferation and inflammatory response by inhibiting the expression of the TGase-2/HMGB1 pathway.
Authors
- Danfang Deng (ORCID: https://orcid.org/0000-0003-0197-2955)
- Ruman Chen (ORCID: https://orcid.org/0000-0002-9231-0174)
- Xiaoqin Wang (ORCID: https://orcid.org/0000-0001-9779-5089)
- Wenjing Wu (ORCID: https://orcid.org/0000-0001-9510-9778)
- Yanping Wu (ORCID: https://orcid.org/0000-0001-8455-3574)
Institutions
- Hubei University of Chinese Medicine (CN)
- Wuhan City Chinese Medicine Hospital (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Hubei 672 Orthopedics Hospital of Traditional Chinese Medicine and Western Medicine (CN)
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s12882-025-04139-7
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province