Accelerated senescence of bone marrow erythrocyte precursors in myelodysplastic syndrome
MDS patients have accelerated senescence of bone marrow erythrocyte precursors, which is related to their anaemia. The observed correlation underscores the potential significance of senescence-targeted interventions in managing anaemia in MDS.<b>Key Messages</b>Bone marrow CD235a⁺ erythroid precursors in MDS patients exhibit accelerated senescence, characterized by cell cycle arrest and increased inflammatory markers. p16INK4A expression negatively correlates with anaemia severity, suggesting senescence as a key contributor to MDS-related anaemia.
Authors
- Limin Xing (ORCID: https://orcid.org/0000-0002-0182-8892)
- Huaquan Wang (ORCID: https://orcid.org/0000-0003-2402-2717)
- Liyan Yang (ORCID: https://orcid.org/0009-0003-8752-8915)
- M Liu (ORCID: https://orcid.org/0000-0002-1257-7662)
- Mengying Zhang (ORCID: https://orcid.org/0000-0001-9802-4913)
- Zonghong Shao (ORCID: https://orcid.org/0000-0002-6069-1275)
- Yumei Liu (ORCID: https://orcid.org/0000-0002-7344-2796)
- Haiyue Niu (ORCID: https://orcid.org/0000-0002-9324-7699)
Institutions
- Capital Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1080/07853890.2025.2494676
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00