Methyl (Z)-2-(Isothioureidomethyl)-2-pentenoate Hydrobromide Induces Cell Cycle Arrest and Disrupts Mitosis in a Melanoma Cell Line
The numerous mechanisms of cell death triggered by IS-MF08 and its drug-likeness make it an interesting molecule in the search for new antitumor compounds, contributing to therapies targeting the dysregulation of cellular mechanisms such as apoptosis.
Authors
- Jelver Sierra (ORCID: https://orcid.org/0000-0001-8541-1535)
- Leônidas João de Mello
- Misael Ferreira (ORCID: https://orcid.org/0000-0002-5893-5306)
- Laura S. Assunção (ORCID: https://orcid.org/0000-0002-2862-4064)
- Flavio A. R. Barbosa (ORCID: https://orcid.org/0000-0002-5021-5072)
- Tânia Beatriz Creczynski‐Pasa (ORCID: https://orcid.org/0000-0002-6026-2948)
- Marcus M. Sá (ORCID: https://orcid.org/0000-0002-9189-1624)
- Iara Fabrícia Kretzer (ORCID: https://orcid.org/0000-0003-1228-7670)
Institutions
- Universidade Federal de Santa Catarina (BR)
- Polydoro Ernani de São Thiago University Hospital (BR)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-04-25
- DOI
- https://doi.org/10.2174/0118715206358941250413154017
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00