Shenhuang Liuwei Powder Alleviates Streptozotocin-Induced Diabetic Ulcers in Rats through the Inhibition of the AGE/RAGE Signaling Pathway and Promotion of Antibacterial Activity and Angiogenesis via Activation of the PI3K/Akt/eNOS/HIF-1α Pathway
SHLWP alleviated streptozotocin-induced diabetic ulcers by inhibiting the AGE/RAGE pathway and promoting antibacterial activity and angiogenesis via the PI3K/Akt/eNOS/HIF-1α pathway, providing a biological basis for its therapeutic effects.
Authors
- Fengye Zhou
- Shu Wang (ORCID: https://orcid.org/0000-0002-8651-4795)
- Shengnan Li (ORCID: https://orcid.org/0000-0002-0257-4708)
- Jun Li (ORCID: https://orcid.org/0000-0001-8243-5267)
- Haifeng Zhang (ORCID: https://orcid.org/0000-0002-3812-1479)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-2652-3988)
- Jianping Chen (ORCID: https://orcid.org/0000-0001-7617-2800)
Institutions
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-04-25
- DOI
- https://doi.org/10.2174/0113862073370028250326071104
- Citations
- 1
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39