Sesquiterpene Coumarin Ethers and Phenylpropanoids from the Roots of Ferula drudeana, the Putative Anatolian Ecotype of the Silphion Plant

Four new sesquiterpene coumarin ethers (<b>1</b>-<b>4</b>) and a new phenylpropanoid compound (<b>5</b>) were isolated from a hexane extract of the roots of <i>Ferula drudeana</i>, the putative Anatolian ecotype of the silphion plant, in addition to nineteen previously described sesquiterpene coumarins (<b>6</b>-<b>24</b>) and four known phenylpropanoid derivatives (<b>25</b>-<b>28</b>). The structures of these compounds were elucidated by extensive spectroscopic analysis and computational studies. The cytotoxic activities of all isolated compounds were evaluated on renal, malignant pleural mesothelioma (MPM) and colon cancer cell lines. While 11 sesquiterpene coumarin derivatives showed strong-to-moderate cytotoxic activity against the UO31 renal cancer cell line, 13 compounds showed strong cytotoxic activity against the MPM cell line, and four sesquiterpene coumarin derivatives displayed moderate cytotoxic activity against the colon cancer cell line.

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Publication Details

Journal
Molecules
Published
2025-04-25
DOI
https://doi.org/10.3390/molecules30091916
Citations
3
Primary Topic
Plant chemical constituents analysis
Type
article
Field-Weighted Citation Impact
5.25

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article

Sesquiterpene Coumarin Ethers and Phenylpropanoids from the Roots of Ferula drudeana, the Putative Anatolian Ecotype of the Silphion Plant

Ekaterina I. Goncharova, Antony Wamiru, Mahmut Miski, Ji-Yeon Hwang et al.
3 citations
Molecules
Plant chemical constituents analysis
5.25
article

Sesquiterpene Coumarin Ethers and Phenylpropanoids from the Roots of Ferula drudeana, the Putative Anatolian Ecotype of the Silphion Plant

Ekaterina I. Goncharova, Antony Wamiru, Mahmut Miski, Ji-Yeon Hwang, Dongdong Wang, Jennifer A. Wilson, Fadıl Kaan Kuran, Sarath P. D. Senadeera, Lin Du, Chuong D. Hoang, Brice A. P. Wilson, John A. Beutler, Nathanael Pruett
article en
3 citations

Abstract

Four new sesquiterpene coumarin ethers (<b>1</b>-<b>4</b>) and a new phenylpropanoid compound (<b>5</b>) were isolated from a hexane extract of the roots of <i>Ferula drudeana</i>, the putative Anatolian ecotype of the silphion plant, in addition to nineteen previously described sesquiterpene coumarins (<b>6</b>-<b>24</b>) and four known phenylpropanoid derivatives (<b>25</b>-<b>28</b>). The structures of these compounds were elucidated by extensive spectroscopic analysis and computational studies. The cytotoxic activities of all isolated compounds were evaluated on renal, malignant pleural mesothelioma (MPM) and colon cancer cell lines. While 11 sesquiterpene coumarin derivatives showed strong-to-moderate cytotoxic activity against the UO31 renal cancer cell line, 13 compounds showed strong cytotoxic activity against the MPM cell line, and four sesquiterpene coumarin derivatives displayed moderate cytotoxic activity against the colon cancer cell line.

MoleculesVol. 30(9)
Target (United States) (US), Frederick National Laboratory for Cancer Research (US), National Cancer Institute (US), Istanbul University (TR)
U.S. Department of Health and Human Services, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, National Institutes of Health, National Cancer Institute
Openalex Percentile: Top 6%
Plant chemical constituents analysis
5.25
DOIOpen Access PDFOpenAlex
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