MMP-10 Gene Polymorphism as a Risk Factor for Pelvic Organ Prolapse in Balinese Women

Background: Pelvic Organ Prolapse (POP) is a prevalent condition among women, particularly in the elderly population, as it is associated with increased morbidity and a decline in quality of life. This disorder results from weakening pelvic support structures, leading to positional and functional abnormalities of the pelvic organs. Genetic factors, including polymorphisms in the MMP-10 gene, are believed to influence susceptibility to POP significantly. Methods: This research utilized an observational case-control design, including 30 women diagnosed with POP (case group) and 30 women without POP (control group). Venous blood samples (3 mL) were collected in EDTA tubes for DNA extraction and analysis of gene polymorphisms. Potential confounding factors such as parity, body mass index (BMI), and occupation were controlled through multivariate logistic regression analysis. Results: The study found that MMP-10 gene polymorphism was a significant risk factor for POP. Women with this polymorphism had a 3.280 times higher likelihood of developing POP than those without it (adjusted OR = 3.280; 95% CI = 1.322–29.818; p = 0.021), even after adjusting for potential confounders. Conclusion: These results suggest that MMP-10 gene polymorphism increases the risk of POP in Balinese women. Identifying this genetic variation could aid in early prevention strategies and enhance clinical management for high-risk individuals.