Reasons for discontinuing and restarting lithium multiple times: a case-register study based on the South London and Maudsley NHS Foundation Trust Clinical Record Interactive Search system
In our sample, lithium was discontinued due to adverse effects in only a minority of patients. In most cases, the reasons for lithium discontinuation were considered psychiatric. Lithium was mainly restarted due to relapse. This warrants a better understanding of the reasons for repeatedly discontinuing lithium and the best way to promote lithium adherence to prevent a perpetual cycle of remitting when on lithium and relapsing when off lithium.
Authors
- Ursula Werneke (ORCID: https://orcid.org/0000-0002-5023-3254)
- David Taylor (ORCID: https://orcid.org/0000-0002-2557-1710)
- Petra Truedson (ORCID: https://orcid.org/0000-0002-8303-1210)
- Kalliopi Vallianatou
- Krister Lindmark (ORCID: https://orcid.org/0000-0002-5756-7791)
- Michael Ott (ORCID: https://orcid.org/0000-0003-2393-9750)
- Martin Maripuu (ORCID: https://orcid.org/0000-0001-7868-8894)
Institutions
- Karolinska University Hospital (SE)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Karolinska Institutet (SE)
- Umeå University (SE)
Publication Details
- Journal
- Therapeutic Advances in Psychopharmacology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1177/20451253251332275
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00