Review of real-world studies on capmatinib use in MET-mutated lung cancer

Lung cancer occupies a leading position in the structure of mortality from malignant neoplasms, so in 2022, mortality from lung cancer was 31.66 per 100,000 population, in 2022, 44,981 patients were registered with a diagnosis of lung cancer for the first time in their life, the one-year mortality rate is 44.8 %. One of the genes involved in the development of lung cancer tumor cells is the MET gene, in which several different mutations have been found, but the deletion of exon 14 is the most common. This mutation occurs in 3–4 % of cases of non-small-cell lung cancer (NSCLC), is an independent factor in poor prognosis, and is associated with short overall survival. The drug capmatinib was first registered in 2020 specifically for treating NSCLC in the presence of a deletion of exon 14 in the MET gene. This study systematically reviewed the real-world clinical practice studies of capmatinib in NSCLC.