Prevalence and molecular characterization of human bocavirus in children with acute gastroenteritis in Beijing, China, during 2014–2023
Acute gastroenteritis remains a leading cause of morbidity and mortality in children, with viral infections being the primary causative agents. In this study, we investigated the prevalence of human bocavirus (HBoVs) in children with acute gastroenteritis in Beijing from 2014 to 2023, identifying HBoV2C as the predominant sub-genotype. Additionally, this study reported the first estimate of the evolutionary rate for global HBoV2 (1.4 × 10<sup>-4</sup> substitutions/site/year) and identified novel intra-genotype recombination events in HBoV2. The results not only filled a gap in the evolutionary studies of global HBoV2 but also offered valuable data for the development of effective surveillance and prevention strategies for controlling acute gastroenteritis in children.
Authors
- Ri De (ORCID: https://orcid.org/0000-0003-1055-1327)
- Hui Huang (ORCID: https://orcid.org/0000-0001-9322-9397)
- Linqing Zhao (ORCID: https://orcid.org/0000-0002-5622-1959)
- Zhenzhi Han (ORCID: https://orcid.org/0000-0003-1772-7946)
- Yan‐Peng Xu (ORCID: https://orcid.org/0000-0001-8764-4412)
- Liying Liu (ORCID: https://orcid.org/0000-0001-6009-5425)
- Li Zeng
- Liping Jia (ORCID: https://orcid.org/0000-0003-4528-7693)
- Kexiang Zhang (ORCID: https://orcid.org/0009-0006-3313-041X)
- Huijin Dong
- Deng Li
Institutions
- Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1128/spectrum.03327-24
- Citations
- 1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China