Pharmacogenomic insights into atorvastatin and rosuvastatin adverse effects: a prospective observational study in the UAE’s multiethnic population
This study highlights the importance of genetic testing and demographic factors, such as ethnicity and gender, in tailoring statin therapy to minimize adverse effects. Despite extensive research on PGx-guided statin prescribing, clinical implementation remains limited. Integrating PGx testing into routine practice and enhancing physician awareness of genetic and demographic risk factors can improve the safety, efficacy, and adherence of lipid-lowering therapies in diverse populations.
Authors
- Zeina N. Al-Mahayri (ORCID: https://orcid.org/0000-0002-4673-6692)
- Mais N. Alqasrawi
- George P. Patrinos (ORCID: https://orcid.org/0000-0002-0519-7776)
- Sahar M. Altoum (ORCID: https://orcid.org/0000-0002-7944-9905)
- Dana Hamza
- Juma Alkaabi (ORCID: https://orcid.org/0000-0003-2477-0408)
- Virendra Misra
- Salahdein Aburuz (ORCID: https://orcid.org/0000-0002-2478-3914)
- Fatma Al‐Maskari (ORCID: https://orcid.org/0000-0001-6598-4942)
- Bassam R. Ali (ORCID: https://orcid.org/0000-0003-1306-6618)
- Areej S. Albawa’neh (ORCID: https://orcid.org/0000-0002-8782-308X)
- Lubna Q. Khasawneh (ORCID: https://orcid.org/0000-0001-6090-5969)
- Husam Ouda
- Lilas Dabaghie
Institutions
- Abu Dhabi University (AE)
- University of Patras (GR)
- United Arab Emirates University (AE)
- Emirates Foundation (AE)
- Al Ain Hospital (AE)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s40246-025-00753-6
- Citations
- 4
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Ministry of Higher Education and Scientific Research
- Ministry of Education, India
- United Arab Emirates University