Characterizing the impact of podophyllotoxin on pulmonary toxicity and gut-lung microbiota interactions in SD rats based on TEC concept
PPT, derived from the medicinal plant <i>Dysosma</i>, is known for its anti-cancer and anti-viral properties but limited by severe pulmonary toxicity. This study illuminates the gut-lung microbiota axis's role in mediating this toxicity, revealing how specific microbial and metabolic alterations contribute to lung damage. By uncovering these mechanisms, our research opens avenues for interventions that could mitigate PPT's side effects, potentially enhancing its safety and widening its therapeutic use.
Authors
- Xiao Ma (ORCID: https://orcid.org/0000-0002-3247-1056)
- Chuanxin Liu (ORCID: https://orcid.org/0000-0002-4492-6150)
- Jiaxing Sun (ORCID: https://orcid.org/0000-0001-8372-5784)
- Jiajia Duan (ORCID: https://orcid.org/0000-0002-7587-1789)
- Junjie He (ORCID: https://orcid.org/0000-0001-6447-7893)
- Feng Cai (ORCID: https://orcid.org/0000-0001-5192-9520)
- Min Wang (ORCID: https://orcid.org/0000-0001-5752-4065)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1128/spectrum.01653-24
- Citations
- 3
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Henan Medical Science and Technique Foundation