Transcriptomic profiling in canine B-cell lymphoma supports a synergistic effect of BTK and PI3K inhibitors
Narrowing in on highly connected genes of modules associated with treatment response with large fold changes across treatments which play roles in the main targeted pathways identified <i>PAG1, PRKAR2A, ACACA, FOS</i>, and <i>PRKCA</i> as potential primary candidates of the synergistic treatment effect.
Authors
- Barbara C. Rütgen (ORCID: https://orcid.org/0000-0001-9080-0164)
- Xenia Lainscsek
- Bertram Brenig (ORCID: https://orcid.org/0000-0002-7635-9656)
- Leila Taher
- Ingo Nölte (ORCID: https://orcid.org/0000-0003-4577-3739)
- Julia Beck (ORCID: https://orcid.org/0009-0001-3683-0431)
- Hugo Murua Escobar (ORCID: https://orcid.org/0000-0001-7123-7986)
- Weibo Kong (ORCID: https://orcid.org/0000-0003-1309-5072)
Institutions
- University of Veterinary Medicine Vienna (AT)
- University of Veterinary Medicine Hannover, Foundation (DE)
- Graz University of Technology (AT)
- University of Rostock (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fvets.2025.1577028
- Citations
- 1
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- TU Graz, Internationale Beziehungen und Mobilitätsprogramme