Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

This study presents an innovative approach utilizing a biocompatible shell to shield bacterial outer membrane vesicles (OMVs) and incorporate Fe ions and ultrasmall Au nanoparticles to develop a combined tumor therapeutic strategy. These chimeric nanozyme shells effectively reduce the toxicity of OMVs during circulation and promote their accumulation in tumor tissues. In the tumor microenvironment, Au nanoparticles act as nanozymes, catalyzing glucose consumption and elevating H₂O₂ levels. The increased H₂O₂ subsequently reacts with the released Fe ions to induce immunogenic tumor cell death through iron-mediated chemodynamic mechanisms. Simultaneously, the release of tumor-associated antigens and OMVs synergistically stimulates the immune response. This cascade of nanozyme-catalyzed reactions, chemodynamic effects, and immune activation results in efficient tumor inhibition.

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Publication Details

Journal
Advanced Science
Published
2025-04-25
DOI
https://doi.org/10.1002/advs.202417712
Citations
3
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
2.02

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article

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

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3 citations
Advanced Science
Nanoplatforms for cancer theranostics
2.02
article

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

Ran Luo, Jianbo Yu, Lin Mei, Huibin Wu, Weiqun Li, Guihong Lu, Qianqian Li, Fan Zhang, Xiang Chen, Feng Li, Haibing Dai, Shanming Lu
article en
3 citations

Abstract

This study presents an innovative approach utilizing a biocompatible shell to shield bacterial outer membrane vesicles (OMVs) and incorporate Fe ions and ultrasmall Au nanoparticles to develop a combined tumor therapeutic strategy. These chimeric nanozyme shells effectively reduce the toxicity of OMVs during circulation and promote their accumulation in tumor tissues. In the tumor microenvironment, Au nanoparticles act as nanozymes, catalyzing glucose consumption and elevating H₂O₂ levels. The increased H₂O₂ subsequently reacts with the released Fe ions to induce immunogenic tumor cell death through iron-mediated chemodynamic mechanisms. Simultaneously, the release of tumor-associated antigens and OMVs synergistically stimulates the immune response. This cascade of nanozyme-catalyzed reactions, chemodynamic effects, and immune activation results in efficient tumor inhibition.

Advanced ScienceVol. 12(22)
Sun Yat-sen University (CN), Chinese Academy of Sciences (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Longgang Central Hospital (CN), Shenzhen Bay Laboratory (CN), Shenzhen Children's Hospital (CN)
National Natural Science Foundation of China, Chinese Academy of Medical Sciences, Natural Science Foundation of Tianjin City, Shenzhen Science and Technology Innovation Program, Basic and Applied Basic Research Foundation of Guangdong Province
Good health and well-being
Openalex Percentile: Top 14%
Nanoplatforms for cancer theranostics
2.02
DOIOpen Access PDFOpenAlex
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