EEG as a predictive biomarker of neurotoxicity in anti-CD19 CAR T-cell therapy
Our study establishes EEG as a predictive tool for identifying patients at risk for ICANS before CAR T-cell infusion, who may benefit from prophylactic treatments, and anticipating ICANS onset following infusion, enabling early intervention.
Authors
- Simone Rossi (ORCID: https://orcid.org/0000-0001-7044-983X)
- Umberto Pensato (ORCID: https://orcid.org/0000-0002-4042-4735)
- Lorenzo Muccioli (ORCID: https://orcid.org/0000-0001-6827-0099)
- Lorenzo Ferri (ORCID: https://orcid.org/0000-0003-0148-9795)
- Roberto D’Angelo (ORCID: https://orcid.org/0000-0002-5862-8074)
- Maria Guarino (ORCID: https://orcid.org/0000-0002-8894-2187)
- Federica Pondrelli (ORCID: https://orcid.org/0000-0002-0241-4587)
- Luisa Sambati (ORCID: https://orcid.org/0000-0002-5939-7933)
- Gian Maria Asioli (ORCID: https://orcid.org/0000-0002-1288-8102)
- Federico Mason (ORCID: https://orcid.org/0000-0001-5681-1695)
- Rita Rinaldi (ORCID: https://orcid.org/0000-0002-4564-7284)
- Enrico Maffini (ORCID: https://orcid.org/0000-0001-7356-2328)
- Valentina Barone (ORCID: https://orcid.org/0000-0003-0402-0052)
- Paolo Tinuper (ORCID: https://orcid.org/0000-0002-0588-3063)
- Corrado Zenesini (ORCID: https://orcid.org/0000-0002-9855-8197)
- Beatrice Casadei (ORCID: https://orcid.org/0000-0002-4453-6064)
- Francesca Bonifazi (ORCID: https://orcid.org/0000-0003-1544-9911)
- Marianna Nicodemo (ORCID: https://orcid.org/0000-0001-7217-9925)
- Francesca Rondelli (ORCID: https://orcid.org/0000-0001-6444-6798)
- Pietro Cortelli (ORCID: https://orcid.org/0000-0002-3633-8818)
- Pier Luigi Zinzani (ORCID: https://orcid.org/0000-0002-2112-2651)
- Francesca Bisulli
- Elisabetta Pierucci
Institutions
- Humanitas University (IT)
- University of Padua (IT)
- Azienda USL di Bologna (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1007/s00415-025-13102-3
- Citations
- 7
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 7.32