Investigating the Anrep Effect in Hypertrophic Obstructive Cardiomyopathy With Invasive Pressure-Volume Analysis
The Anrep effect is an energy-demanding compensatory mechanism that maintains stroke volume under elevated afterload by increasing contractility and prolonging systole. This study confirms its chronic activation in HOCM and its immediate reversal post-PTSMA.
Authors
- Volker Rudolph (ORCID: https://orcid.org/0000-0001-5385-6839)
- Smita Scholtz (ORCID: https://orcid.org/0000-0002-7445-5986)
- Vasco Sequeira (ORCID: https://orcid.org/0000-0002-9192-7674)
- Patrick Serruys
- Christoph Maack (ORCID: https://orcid.org/0000-0003-3694-4559)
- Paul Steendijk (ORCID: https://orcid.org/0000-0002-8454-4499)
- Jan‐Christian Reil (ORCID: https://orcid.org/0000-0003-1053-5175)
- Gert‐Hinrich Reil
Institutions
- University of Würzburg (DE)
- Leiden University Medical Center (NL)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- Universitäts-Kinderklinik Würzburg (DE)
- Klinikum Oldenburg (DE)
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- JACC Advances
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1016/j.jacadv.2025.101728
- Citations
- 5
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- Deutsche Forschungsgemeinschaft
- Ruhr-Universität Bochum
- Julius-Maximilians-Universität Würzburg