GLOMERULOPATIA SECUNDÁRIA A INFECÇÃO TARDIA POR ESQUISTOSSOMOSE – RELATO DE DOIS CASOS EM UM HOSPITAL TERCIÁRIO DO DISTRITO FEDERAL

Schistosomiasis is a parasitic infection caused by Schistosoma mansoni, highly prevalent in areas with poor sanitation infrastructure. Although classically associated with hepatic and intestinal manifestations, the disease can also lead to renal involvement through immune-mediated mechanisms involving immune complexes. This study presents two clinical cases of glomerulopathy associated with schistosomiasis, with different histological patterns: IgA nephropathy and membranous glomerulopathy with membranoproliferative features. Both patients had a history of chronic liver disease and portal hypertension, conditions that favor portosystemic shunting and renal exposure to intestinal antigens. The diagnosis was confirmed through renal biopsy, and both patients showed satisfactory outcomes following specific treatment. The diversity of clinical presentations highlights the importance of including schistosomiasis in the differential diagnosis of glomerulopathies, particularly in endemic regions. Early diagnosis enables appropriate management and can prevent progression to end-stage renal disease. Therefore, the implementation of public policies aimed at improving basic sanitation, controlling the intermediate host, and expanding access to diagnosis and treatment is essential for reducing renal morbidity associated with schistosomiasis.