Allo-Priming Reverses Immunosenescence and May Restore Broad Respiratory Viral Protection and Vaccine Responsiveness to the Elderly: Results of a Phase I/II Clinical Trial
These results provide support for an expanded clinical evaluation of this immunomodulatory vaccination strategy as a possible method to restore cellular immune competence to the elderly and provide broad heterologous immune protection from respiratory viral infections without the need for frequent vaccine re-formulations or booster shots (National Library of Medicine: NCT04441047).
Authors
- Xiaochuan Yang (ORCID: https://orcid.org/0000-0001-7003-444X)
- Canhui Liu (ORCID: https://orcid.org/0000-0001-8491-5096)
- Ryan Shane
- David Sikes (ORCID: https://orcid.org/0000-0003-3465-710X)
- Michael Har-Noy (ORCID: https://orcid.org/0000-0002-9342-9337)
- Nicole Thomas
- Alejandra V. Marin-Ruiz
- Jorge Paoli-Bruno
Institutions
- Orlando Health (US)
- Delray Medical Center (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3390/vaccines13050463
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00